Research interest.

Immediate early immune responder, neutrophils, need a final mechanical stimulation during its passage through restrictive endothelial junction – before entering lung (or other) tissue. Without endothelium derived mechano-sensation, such as in acute respiratory distress syndromes or pneumonia, caused due to the relaxation of endothelial adherens junction, neutrophils do not reach to the activation threshold. Thus, immune responses become dampened, leading to prolonged recovery or mortality .

My studies aim to understand the mechanism of cellular mechanical signal reception, relay, mechano-chemical coupling processes and resultant cellular responses to pathogens or inflammation.