How circulating innate immune cells

sense and respond to mechanical forces

Amitabha Mukhopadhyay

I’m a researcher based out of University of Illinois Chicago. My research focus is to understand the mechanism of mechanical signal relay in neutrophils and innate immune cells.

Publication

1. trans-Endothelial neutrophil migration activates bactericidal function via Piezo1 mechanosensing. 

Immunity. 2023 Dec 12;. doi: 10.1016/j.immuni.2023.11.007. [Epub ahead of print] PubMed PMID: 38091995.

Mukhopadhyay A, Tsukasaki Y, Chan WC, Le JP, Kwok ML, Zhou J, Natarajan V, Mostafazadeh N, Maienschein-Cline M, Papautsky I, Tiruppathi C, Peng Z, Rehman J, Ganesh B, Komarova Y, Malik AB. 

 

2.  Trained immunity of alveolar macrophages enhances injury resolution via KLF4-MERTK-mediated efferocytosis. 

J Exp Med. 2023 Nov 6;220(11). doi: 10.1084/jem.20221388. Epub 2023 Aug 24. PubMed PMID: 37615937; PubMed Central PMCID: PMC10450795.

Chakraborty S, Singh A, Wang L, Wang X, Sanborn MA, Ye Z, Maienschein-Cline M, Mukhopadhyay A, Ganesh BB, Malik AB, Rehman J. 

 

3. Ubiquitin ligase CHFR mediated degradation of VE-cadherin through ubiquitylation disrupts endothelial adherens junctions. 

Nat Commun. 2023 Oct 18;14(1):6582. doi: 10.1038/s41467-023-42225-2. PubMed PMID: 37852964; PubMed Central PMCID: PMC10584835.

Tiruppathi C, Wang DM, Ansari MO, Bano S, Tsukasaki Y, Mukhopadhyay A, Joshi JC, Loch C, Niessen HWM, Malik AB. 

 

4. Nanoparticle targeting of de novo profibrotic macrophages mitigates lung fibrosis. 

Proc Natl Acad Sci U S A. 2022 Apr 12;119(15):e2121098119. doi: 10.1073/pnas.2121098119. Epub 2022 Apr 4. PubMed PMID: 35377803; PubMed Central PMCID: PMC9169714.

Singh A, Chakraborty S, Wong SW, Hefner NA, Stuart A, Qadir AS, Mukhopadhyay A, Bachmaier K, Shin JW, Rehman J, Malik AB. 

 

5. Albumin Nanoparticle Endocytosing Subset of Neutrophils for Precision Therapeutic Targeting of Inflammatory Tissue Injury. 

ACS Nano. 2022 Mar 22;16(3):4084-4101. doi: 10.1021/acsnano.1c09762. Epub 2022 Mar 1. PubMed PMID: 35230826; PubMed Central PMCID: PMC8945372.

Bachmaier K, Stuart A, Singh A, Mukhopadhyay A, Chakraborty S, Hong Z, Wang L, Tsukasaki Y, Maienschein-Cline M, Ganesh BB, Kanteti P, Rehman J, Malik AB. 

 

6.  CD38-mediated Inhibition of Bruton's Tyrosine Kinase in Macrophages Prevents Endotoxemic Lung Injury. 

Am J Respir Cell Mol Biol. 2022 Feb;66(2):183-195. doi: 10.1165/rcmb.2021-0272OC. PubMed PMID: 34706199; PubMed Central PMCID: PMC8845142.

Farahany J, Tsukasaki Y, Mukhopadhyay A, Mittal M, Nepal S, Tiruppathi C, Malik AB. 

 

7. Selective Nanotherapeutic Targeting of the Neutrophil Subset Mediating Inflammatory Injury.

bioRxiv. 2020 June; 180927. doi: https://doi.org/10.1101/2020.06.30.180927.

Bachmaier K, Stuart A, Hong Z, Tsukasaki Y, Singh A, Chakraborty S, Mukhopadhyay A, Gao X, Maienschein-Cline M, Kanteti P, Rehman J, Malik A. 

 

8. Recording Ion Channels in Cilia Membranes. In: Polycystic Kidney Disease

Book Chapter (Polycystic Kidney Disease); First Published 2019. CRC Press, Routledge Taylor & Francis; 1st Edition; Pages18, eBook ISBN 9780429468834

Ng LC, Mukhopadhyay A, Vien N, DeCaen PG. 

 

9. 14-3-3γ Prevents Centrosome Amplification and Neoplastic Progression. 

Sci Rep. 2016 Jun 2;6:26580. doi: 10.1038/srep26580. PubMed PMID: 27253419; PubMed Central PMCID: PMC4890593.

Mukhopadhyay A, Sehgal L, Bose A, Gulvady A, Senapati P, Thorat R, Basu S, Bhatt K, Hosing AS, Balyan R, Borde L, Kundu TK, Dalal SN. 

 

10. 14-3-3γ-Mediated transport of plakoglobin to the cell border is required for the initiation of desmosome assembly in vitro and in vivo. 

J Cell Sci. 2014 May 15;127(Pt 10):2174-88. doi: 10.1242/jcs.125807. Epub 2014 Mar 7. PubMed PMID: 24610948.

Sehgal L, Mukhopadhyay A, Rajan A, Khapare N, Sawant M, Vishal SS, Bhatt K, Ambatipudi S, Antao N, Alam H, Gurjar M, Basu S, Mathur R, Borde L, Hosing AS, Vaidya MM, Thorat R, Samaniego F, Kolthur-Seetharam U, Dalal SN. 

 

11. Generation of HIV-1 based bi-cistronic lentiviral vectors for stable gene expression and live cell imaging. 

Indian J Exp Biol. 2012 Oct;50(10):669-76. PubMed PMID: 23214259.

Sehgal L, Budnar S, Bhatt K, Sansare S, Mukhopadhaya A, Kalraiya RD, Dalal SN. 

12. Lentiviral mediated transgenesis by in vivo manipulation of spermatogonial stem cells. 

PLoS One. 2011;6(7):e21975. doi: 10.1371/journal.pone.0021975. Epub 2011 Jul 7. PubMed PMID: 21760937; PubMed Central PMCID: PMC3131306.

Sehgal L, Thorat R, Khapare N, Mukhopadhaya A, Sawant M, Dalal SN.

Current Location

Chicago, Illinois